The emerging role of physiologically based pharmacokinetic modelling in solid drug nanoparticle translation



Siccardi, Marco ORCID: 0000-0002-3539-7867, Rannard, Steve ORCID: 0000-0002-6946-1097 and Owen, Andrew ORCID: 0000-0002-9819-7651
(2018) The emerging role of physiologically based pharmacokinetic modelling in solid drug nanoparticle translation. Advanced Drug Delivery Reviews, 131. pp. 116-121.

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Abstract

The use of solid drug nanoparticles (SDN) has become an established approach to improve drug delivery, supporting enhancement of oral absorption and long-acting administration strategies. A broad range of SDNs have been successfully utilised for multiple products and several development programmes are currently underway across different therapeutic areas. With some approaches, a large range of material space is available with diversity in physical characteristics, excipient choice and pharmacological behaviour. The selection of SDN lead candidates is a complex process including a broad range of in vitro and in vivo data, and a better understanding of how physical characteristics relate to performance is required. Physiologically-based pharmacokinetic (PBPK) modelling is based upon a comprehensive integration of experimental data into a mathematical description of drug distribution, allowing simulation of SDN pharmacokinetics that can be qualified in vivo prior to human prediction. This review aims to provide a description of how PBPK can find application into the development of SDN. Integration of predictive PBPK modelling into SDN development allows a better understanding of the SDN dose-response relationship, supporting a framework for rational optimisation while reducing the risk of failure in developing safe and effective nanomedicines.

Item Type: Article
Uncontrolled Keywords: Solid drug nanoparticle, Pharmacokinetics, Physiologicallybased Pharmacokinetic (PBPK) modelling, Design
Depositing User: Symplectic Admin
Date Deposited: 14 Sep 2018 13:09
Last Modified: 19 Jan 2023 01:17
DOI: 10.1016/j.addr.2018.06.016
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3026280

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