Iron-Catalyzed Alkylation of Nitriles with Alcohols

Ma, Wei, Cui, Suiya, Sun, Huamin, Tang, Weijun, Xue, Dong, Li, Chaoqun, Fan, Juan, Xiao, Jianliang ORCID: 0000-0003-2010-247X and Wang, Chao
(2018) Iron-Catalyzed Alkylation of Nitriles with Alcohols. CHEMISTRY-A EUROPEAN JOURNAL, 24 (50). pp. 13118-13123.

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A general, efficient iron-catalyzed α-alkylation of nitriles with primary alcohols through a hydrogen-borrowing pathway has been developed, allowing a wide variety of alkylated nitriles to be readily accessible. Detailed mechanistic studies suggest that the reaction proceeds via an olefin intermediate with the turnover rate limited by the hydrogenation of the olefin with an iron hydride. Apart from participating in the alkylation, the nitrile is found to play an important role in promoting the formation of and stabilizing the active catalytic species.

Item Type: Article
Uncontrolled Keywords: alcohols, alkylation, hydrogen transfer, iron catalysis, nitriles
Depositing User: Symplectic Admin
Date Deposited: 20 Sep 2018 10:13
Last Modified: 19 Jan 2023 01:16
DOI: 10.1002/chem.201803762
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