Management of skin, mucosa and joint involvement of Behcet's syndrome: A systematic review for update of the EULAR recommendations for the management of Behcet's syndrome



Leccese, Pietro, Ozguler, Yesim, Christensen, Robin, Esatoglu, Sinem Nihal, Bang, Dongsik, Bodaghi, Bahram, Celik, Aykut Ferhat, Fortune, Farida, Gaudric, Julien, Gul, Ahmet
et al (show 16 more authors) (2019) Management of skin, mucosa and joint involvement of Behcet's syndrome: A systematic review for update of the EULAR recommendations for the management of Behcet's syndrome. SEMINARS IN ARTHRITIS AND RHEUMATISM, 48 (4). pp. 752-762.

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Abstract

<h4>Objectives</h4>The aim of this systematic review was to inform the update of European League Against Rheumatism (EULAR) Recommendations for the management of Behçet's syndrome (BS), on the evidence for the treatment of skin, mucosa and joint involvement of BS.<h4>Methods</h4>A systematic literature search, data extraction, statistical analyses and assessment of the quality of evidence were performed according to a pre-specified protocol using the PRISMA guidelines. Studies that assessed the efficacy of an intervention in comparison to an active comparator or placebo for oral ulcers, genital ulcers, papulopustular lesions, nodular lesions or arthritis were included. Where possible, risk ratios were calculated for binary outcomes and mean difference for continuous outcomes.<h4>Results</h4>Among the 3927 references that were screened, 37 were included in the analyses. Twenty-seven of these assessed mucocutaneous and 17 assessed joint involvement. Twenty-one of these studies were randomised controlled trials (RCTs). RCTs with colchicine, azathioprine, interferon-alpha, thalidomide, etanercept and apremilast showed beneficial results with some differences according to lesion type and gender. These agents were generally well tolerated with few adverse events causing withdrawal from the study.<h4>Conclusions</h4>RCTs comprised more than a half (21/37, 57%) of the sources included in the evidence synthesis related to skin, mucosa and joint involvement applicable for the EULAR Recommendations for the management of BS. Differences in the outcome measures that were used across the included studies often made it difficult to combine and compare the results.

Item Type: Article
Uncontrolled Keywords: Behcet's disease, Treatment, Anti-TNF, Systematic review
Depositing User: Symplectic Admin
Date Deposited: 19 Oct 2018 10:41
Last Modified: 19 Jan 2023 01:15
DOI: 10.1016/j.semarthrit.2018.05.008
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3026888