Histocytic-like Atypical Mast Cell Tumours in Horses

Elbahi, A, Kipar, A ORCID: 0000-0001-7289-3459 and Ressel, L ORCID: 0000-0002-6614-1223
(2018) Histocytic-like Atypical Mast Cell Tumours in Horses. JOURNAL OF COMPARATIVE PATHOLOGY, 162. pp. 14-17.

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This report describes a series of four equine mast cell tumours (MCTs) with atypical morphological features. The tumours were 1-2 cm in diameter and mostly localized to the eyes (one eyelid, two conjunctiva). Histologically, they were composed of very large (up to 35 μm) round pleomorphic cells with a large central to paracentral nucleus and abundant granular cytoplasm. A large number of viable mature eosinophils were detected intermingled with the large round cells. Histochemical staining (toluidine blue and Perls' Prussian blue) and immunohistochemistry (KIT, mast cell tryptase, lysozyme and proliferating cell nuclear antigen) confirmed the mast cell origin of the atypical cells and identified an aberrant KIT protein expression in three cases. Based on morphological and immunohistochemical features, we propose to call the lesions equine histiocytic-like atypical MCTs.

Item Type: Article
Uncontrolled Keywords: atypical, histiocytic-like, horse, mast cell tumour
Depositing User: Symplectic Admin
Date Deposited: 11 Oct 2018 10:29
Last Modified: 19 Jan 2023 01:15
DOI: 10.1016/j.jcpa.2018.05.003
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3027352