RAS variant signalling



Mo, Stephanie P, Coulson, Judy M ORCID: 0000-0003-2191-2001 and Prior, Ian A ORCID: 0000-0002-4055-5161
(2018) RAS variant signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 46 (5). pp. 1325-1332.

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Abstract

RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent findings describing how RAS isoforms and different activating mutations differentially contribute to normal and disease-associated biology and the mechanisms that have been proposed to underpin this.

Item Type: Article
Uncontrolled Keywords: Cell Membrane, Animals, Humans, Neoplasms, ras Proteins, Protein Isoforms, Developmental Disabilities, Signal Transduction, Cell Proliferation, Mutation, Protein Multimerization
Depositing User: Symplectic Admin
Date Deposited: 10 Oct 2018 15:10
Last Modified: 19 Jan 2023 01:14
DOI: 10.1042/BST20180173
Open Access URL: https://doi.org/10.1042/BST20180173
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3027366