Mo, Stephanie P, Coulson, Judy M ORCID: 0000-0003-2191-2001 and Prior, Ian A ORCID: 0000-0002-4055-5161
(2018)
RAS variant signalling.
BIOCHEMICAL SOCIETY TRANSACTIONS, 46 (5).
pp. 1325-1332.
Abstract
RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent findings describing how RAS isoforms and different activating mutations differentially contribute to normal and disease-associated biology and the mechanisms that have been proposed to underpin this.
Item Type: | Article |
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Uncontrolled Keywords: | Cell Membrane, Animals, Humans, Neoplasms, ras Proteins, Protein Isoforms, Developmental Disabilities, Signal Transduction, Cell Proliferation, Mutation, Protein Multimerization |
Depositing User: | Symplectic Admin |
Date Deposited: | 10 Oct 2018 15:10 |
Last Modified: | 19 Jan 2023 01:14 |
DOI: | 10.1042/BST20180173 |
Open Access URL: | https://doi.org/10.1042/BST20180173 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3027366 |