Five-year single-centre experience of carcinoma of the oesophagus from Blantyre, Malawi.

Chetwood, John David ORCID: 0000-0002-8947-9817, Finch, Peter J, Kankwatira, Anstead, Mallewa, Jane, Gordon, Melita A and Masamba, Leo
(2018) Five-year single-centre experience of carcinoma of the oesophagus from Blantyre, Malawi. BMJ open gastroenterology, 5 (1). e000232 - ?.

Access the full-text of this item by clicking on the Open Access link.


<h4>Background</h4>Oesophageal squamous cell carcinoma (OSCC) is increasing worldwide and has an exceptionally high prevalence in certain distinct geographical locations such as the African oesophageal SCC corridor. Despite this, there is a paucity of evidence to characterise the disease particularly in the Malawian context.<h4>Method</h4>We retrospectively audited our endoscopy database over 5 years, including for patient demographics, endoscopy findings, therapeutic intervention and recommendations for treatment.<h4>Results</h4>1586 patients with oesophageal cancer were identified from a total of 5882 endoscopy records from 2013 to 2017. Our cohort showed a larger proportion of oesophageal cancers found higher in the oesophagus compared with other African studies and a female preponderance in this upper-oesophagus disease subset though a male preponderance overall. 39% of patients with oesophageal cancer underwent bougie dilatation and 11% underwent palliative stent placement, which likely reflects local availability of resources.<h4>Conclusion</h4>This study validates the observation that OSCC predominates in sub-Saharan Africa in Malawi over other forms of oesophageal carcinoma, though our cohort appears to have subtly distinct demographics and disease-specific data. This highlights the need to prioritise preventative and therapeutic strategies for OSCC in this and similar settings.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 17 Oct 2018 15:37
Last Modified: 06 Oct 2022 05:47
DOI: 10.1136/bmjgast-2018-000232
Open Access URL: