Drug repurposing: progress, challenges and recommendations

Pushpakom, Sudeep ORCID: 0000-0002-6682-4235, Iorio, Francesco, Eyers, Patrick A ORCID: 0000-0002-9220-2966, Escott, K Jane, Hopper, Shirley, Wells, Andrew, Doig, Andrew, Guilliams, Tim, Latimer, Joanna, McNamee, Christine
et al (show 4 more authors) (2019) Drug repurposing: progress, challenges and recommendations. NATURE REVIEWS DRUG DISCOVERY, 18 (1). pp. 41-58.

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Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines. Various data-driven and experimental approaches have been suggested for the identification of repurposable drug candidates; however, there are also major technological and regulatory challenges that need to be addressed. In this Review, we present approaches used for drug repurposing (also known as drug repositioning), discuss the challenges faced by the repurposing community and recommend innovative ways by which these challenges could be addressed to help realize the full potential of drug repurposing.

Item Type: Article
Uncontrolled Keywords: Humans, Drug Industry, Drug Discovery, Drug Repositioning
Depositing User: Symplectic Admin
Date Deposited: 25 Oct 2018 08:49
Last Modified: 19 Jan 2023 01:14
DOI: 10.1038/nrd.2018.168
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3027906