Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling


Lin, H, Pei, C, Markl, D, Shen, Y ORCID: 0000-0002-8915-1993, Elliott, JA and Axel Zeitler, J (2018) Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. IET Microwaves, Antennas and Propagation, 12 (11). pp. 1775-1779. ISSN 1751-8725, 1751-8733

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Abstract

© The Institution of Engineering and Technology 2018. In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.

Item Type: Article
Uncontrolled Keywords: pharmaceuticals, coatings, pharmaceutical industry, ray tracing, mixing, discrete element method, numerical verification, tablet mixing, discrete element modelling, terahertz in-line sensing, film coating thickness, individual pharmaceutical tablets, measurement analysis, cumulative measurements, discrete modelling, tablet pan coater, artificial lab-scale tablet, terahertz in-line measurement modality, off-line measurements, in-line measurements, coating process
Depositing User: Symplectic Admin
Date Deposited: 14 Nov 2018 08:55
Last Modified: 07 Dec 2024 05:10
DOI: 10.1049/iet-map.2018.5561
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3028788
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