Age-related changes in skeletal muscle: changes to life-style as a therapy

McCormick, R and Vasilaki, A ORCID: 0000-0002-5652-0895 (2018) Age-related changes in skeletal muscle: changes to life-style as a therapy Biogerontology, 19 (6). pp. 519-536. ISSN 1389-5729, 1573-6768

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Abstract

As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is there-fore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with changes in numerous important mechanisms all contributing to the structural and functional deterioration. Here, we review the major proposed changes which occur in skeletal muscle during ageing and highlight evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting.

Item Type:	Article
Uncontrolled Keywords:	Sarcopenia, Skeletal muscle ageing, Muscle wasting, Sarcopenic therapeutics
Depositing User:	Symplectic Admin
Date Deposited:	03 Dec 2018 16:18
Last Modified:	22 Jan 2026 01:01
DOI:	10.1007/s10522-018-9775-3
Open Access URL:	https://link.springer.com/content/pdf/10.1007/s105...
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3029441
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