Psychoradiological investigations of gray matter alterations in patients with anorexia nervosa



Zhang, Simin, Wang, Weina, Su, Xiaorui, Kemp, Graham J ORCID: 0000-0002-8324-9666, Yang, Xibiao, Su, Jingkai, Tan, Qiaoyue, Zhao, Youjin, Sun, Huaiqiang, Yue, Qiang
et al (show 1 more authors) (2018) Psychoradiological investigations of gray matter alterations in patients with anorexia nervosa. TRANSLATIONAL PSYCHIATRY, 8 (1). 277-.

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Abstract

Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality. The underlying neurobiological mechanisms are not well understood, and high-resolution structural magnetic resonance brain imaging studies have given inconsistent results. Here we aimed to psychoradiologically define the most prominent and replicable abnormalities of gray matter volume (GMV) in AN patients, and to examine their relationship to demographics and clinical characteristics, by means of a new coordinate-based meta-analytic technique called seed-based d mapping (SDM). In a pooled analysis of all AN patients we identified decreased GMV in the bilateral median cingulate cortices and posterior cingulate cortices extending to the bilateral precuneus, and the supplementary motor area. In subgroup analysis we found an additional decreased GMV in the right fusiform in adult AN, and a decreased GMV in the left amygdala and left anterior cingulate cortex in AN patients without comorbidity (pure AN). Thus, the most consistent GMV alterations in AN patients are in the default mode network and the sensorimotor network. These psychoradiological findings of the brain abnormalities might underpin the neuropathophysiology in AN.

Item Type: Article
Uncontrolled Keywords: Brain, Humans, Magnetic Resonance Imaging, Anorexia Nervosa, Image Processing, Computer-Assisted, Adolescent, Adult, Female, Male, Young Adult, Gray Matter
Depositing User: Symplectic Admin
Date Deposited: 07 Jan 2019 11:32
Last Modified: 19 Jan 2023 01:08
DOI: 10.1038/s41398-018-0323-3
Open Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC62933...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3030767