Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis



Merga, YJ, O Hara, A, Burkitt, MD ORCID: 0000-0002-5055-6408, Duckworth, CA, Probert, CS ORCID: 0000-0003-4550-0239, Campbell, BJ ORCID: 0000-0002-7407-012X and Pritchard, DM ORCID: 0000-0001-7971-3561
(2016) Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310 (11). G1081 - G1090.

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Abstract

© 2016 the American Physiological Society.Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett’s esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 04 Jan 2019 15:09
Last Modified: 24 Mar 2020 23:10
DOI: 10.1152/ajpgi.00026.2016
URI: http://livrepository.liverpool.ac.uk/id/eprint/3030794

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