Cucchetti, A, Russolillo, N, Johnson, P 
ORCID: 0000-0003-1404-0209, Tarchi, P, Ferrero, A, Cucchi, M, Serenari, M, Ravaioli, M, de Manzini, N, Cescon, M et al (show 1 more authors)
(2019)
Impact of primary cancer features on behaviour of colorectal liver metastases and survival after hepatectomy.
BJS OPEN, 3 (2).
pp. 186-194.
Abstract
<h4>Background</h4>Markers of tumour biology may be valuable prognostic indicators after hepatic resection of colorectal cancer liver metastases (CRLMs). Identification of the aggressiveness of these metastases might inform the appropriateness of hepatic surgery.<h4>Methods</h4>Patients undergoing liver resection for CRLMs between January 2001 and July 2013 in four tertiary hospitals were reviewed. A mathematical model to estimate CRLM doubling times was constructed for patients with metachronous metastases. Tumour doubling time was investigated in relation to the features of colorectal cancer, including <i>KRAS</i> status. The hazard rate for recurrence and death following hepatectomy was explored through the Kernel-smoothed estimator.<h4>Results</h4>Of 1063 patients undergoing liver resection for CRLMs, 361 with metachronous metastases undergoing single-stage hepatectomy were analysed. The mean doubling time in patients not receiving chemotherapy between surgery for colorectal cancer and CRLM was 71·4 days. Tumour doubling time was shorter in patients with more advanced primary tumour stages, with mutant <i>KRAS</i> and in those who did not receive chemotherapy. For fast-growing CRLMs (doubling time less than 48 days), the risk of recurrence was highest within the first postoperative year, and was about 7 per cent per month.<h4>Conclusion</h4>Primary features of colorectal cancer were linked to aggressiveness of CRLMs as measured by doubling time.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Colon, Rectum, Humans, Colorectal Neoplasms, Liver Neoplasms, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Disease-Free Survival, Hepatectomy, Tumor Burden, Follow-Up Studies, Models, Biological, Time Factors, Aged, Middle Aged, Female, Male, Proto-Oncogene Proteins p21(ras) |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Jan 2019 11:39 |
| Last Modified: | 19 Jan 2023 01:06 |
| DOI: | 10.1002/bjs5.100 |
| Open Access URL: | https://onlinelibrary.wiley.com/doi/epdf/10.1002/b... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3031793 |
Dimensions
Dimensions
