Extent of resection predicts risk of progression in adult pilocytic astrocytoma.



Nelson, Andrew J ORCID: 0000-0001-7430-9543, Zakaria, Rasheed ORCID: 0000-0001-6826-2662, Jenkinson, Michael D ORCID: 0000-0003-4587-2139 and Brodbelt, Andrew R
(2019) Extent of resection predicts risk of progression in adult pilocytic astrocytoma. British journal of neurosurgery. 1 - 5.

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Abstract

OBJECT:Pilocytic astrocytomas are rare tumours in adults. Presentation, management and prognostic factors are poorly characterised. METHODS:Retrospective single centre study from 2000 to 2016. RESULTS:50 cases were identified (median age 29 years; range 16-76). Symptoms at presentation were neurological deficit (n = 21), headache (n = 18) and seizures (n = 6). Five were incidental findings. Five patients had hydrocephalus at presentation and required emergent management, two by endoscopic third ventriculostomy and three by external ventricular drain. Symptoms were present for a median of 16 weeks (range 1 week to 34 years). Surgery consisted of gross total resection (n = 23), subtotal resection (n = 21) or biopsy (n = 6). Progression occurred in 20 patients at a median time of 7 years following surgery and was asymptomatic in just over half of these cases. A greater degree of resection (complete vs. subtotal) was associated with longer time to progression (Kaplan-Meier analysis, log rank test = 3.58, p = 0.059). At their first progression 12 patients underwent re-resective surgery and the remainder received radiotherapy. The median 5-year survival was 80%. CONCLUSIONS:In adult patients with a pilocytic astrocytoma, a macroscopic resection should be the aim at the first resective operation. Emergency management of hydrocephalus may be required in the first instance.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 01 Feb 2019 08:39
Last Modified: 09 Oct 2019 10:12
DOI: 10.1080/02688697.2018.1549315
URI: http://livrepository.liverpool.ac.uk/id/eprint/3032084
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