Proteomic dataset of wolframin-deficient mouse heart and skeletal muscles

Eimre, Margus, Kasvandik, Sergo, Ivask, Marilin and Koks, Sulev ORCID: 0000-0001-6087-6643
(2018) Proteomic dataset of wolframin-deficient mouse heart and skeletal muscles. DATA IN BRIEF, 21. pp. 616-619.

Access the full-text of this item by clicking on the Open Access link.


The data presented in this article are related to the research article entitled "Increased Mitochondrial Protein Levels and Bioenergetics in the <i>musculus rectus femoris</i> of Wfs1-Deficient mice" (Eimre et al., accepted for publication). This dataset reports the analysis of Wfs1-deficient mouse heart, <i>musculus soleus</i>, and white part of <i>musculus rectus femoris</i> by liquid chromatography/tandem mass spectrometry. Label-free quantitative analysis of the mass spectrometry data identified 4056 proteins, with 114, 212, and 1290 proteins differentially expressed (<i>t</i>-test; <i>p</i> < 0.05) in the heart, <i>m</i>. <i>soleus</i>, and <i>m. rectus femoris</i>, respectively, between the Wfs1-deficient and wild-type groups. Eight proteins were found to be differentially expressed in all mentioned muscles, with 1 protein differently expressed in oxidative (<i>m. soleus</i> and heart) and 88 in skeletal muscles. This dataset supports the cited study and can be used to extend additional analyses. Data are available via ProteomeXchange with identifier PXD011019.

Item Type: Article
Uncontrolled Keywords: Wolfram syndrome, Wfs1, Myocardium, skeletal muscle, Animal proteomics
Depositing User: Symplectic Admin
Date Deposited: 01 Feb 2019 09:08
Last Modified: 19 Jan 2023 01:05
DOI: 10.1016/j.dib.2018.10.015
Open Access URL:
Related URLs: