Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi.



Bennett, Aisleen, Pollock, Louisa, Jere, Khuzwayo C ORCID: 0000-0003-3376-8529, Pitzer, Virginia E, Lopman, Benjamin, Parashar, Umesh, Everett, Dean, Heyderman, Robert S, Bar-Zeev, Naor ORCID: 0000-0003-0570-4624, Cunliffe, Nigel A ORCID: 0000-0002-5449-4988
et al (show 1 more authors) (2019) Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi. The Journal of infectious diseases.

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Abstract

Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8-10 days after vaccine). RV1 vaccine virus in stool was detected using semiquantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 04 Feb 2019 10:05
Last Modified: 20 Mar 2020 22:13
DOI: 10.1093/infdis/jiz002
URI: http://livrepository.liverpool.ac.uk/id/eprint/3032125