Bennett, Aisleen, Pollock, Louisa, Jere, Khuzwayo C ORCID: 0000-0003-3376-8529, Pitzer, Virginia E, Lopman, Benjamin, Parashar, Umesh, Everett, Dean, Heyderman, Robert S, Bar-Zeev, Naor ORCID: 0000-0003-0570-4624, Cunliffe, Nigel A ORCID: 0000-0002-5449-4988 et al (show 1 more authors)
(2019)
Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi.
The Journal of Infectious Diseases, 219 (11).
pp. 1730-1734.
Text
jiz002.pdf - Published version Download (166kB) |
Abstract
Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8-10 days after vaccine). RV1 vaccine virus in stool was detected using semiquantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.
Item Type: | Article |
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Uncontrolled Keywords: | rotavirus, vaccine, indirect effects, transmission, Malawi |
Depositing User: | Symplectic Admin |
Date Deposited: | 04 Feb 2019 10:05 |
Last Modified: | 19 Jan 2023 01:05 |
DOI: | 10.1093/infdis/jiz002 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3032125 |