Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host

Clerc, Melanie, Fenton, AC ORCID: 0000-0002-7676-917X, Babayan, Simon and Pedersen, Amy (2019) Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host. Parasitology, 146 (8). pp. 1096-1106.

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Abstract

Within-host interactions among coinfecting parasites are common and have important consequences for host health and disease dynamics. However, these within-host interactions have traditionally been studied in laboratory mouse models, which often exclude important variation and use unnatural host–parasite combinations. Conversely, the few wild studies of within-host interactions often lack knowledge of parasite exposure and infection history. Here we exposed laboratory-reared wood mice (Apodemus sylvaticus) that were derived from wild-caught animals to two naturally-occurring parasites (nematode: Heligmosomoides polygyrus, coccidia: Eimeria hungaryensis) to investigate the impact of coinfection on parasite infection dynamics, and to determine if the host immune response mediates this interaction. Coinfection led to delayed worm expulsion and prolonged egg shedding in H. polygyrus infections and lower peak E. hungaryensis oocyst burdens. By comparing antibody levels between wild and colony-housed mice, we also found that wild mice had elevated H. polygyrus-IgG1 titres even if currently uninfected with H. polygyrus. Using this unique wild-laboratory system, we demonstrate, for the first time, clear evidence for a reciprocal interaction between these intestinal parasites, and that there is a great discrepancy between antibody levels measured in the wild vs those measured under controlled laboratory conditions in relation to parasite infection and coinfection.

Item Type:	Article
Uncontrolled Keywords:	Coinfection, Eimeria hungaryensis, Heligmosomoides polygyrus, Laboratory systems, Wild mice
Depositing User:	Symplectic Admin
Date Deposited:	04 Feb 2019 11:58
Last Modified:	19 Jan 2023 01:05
DOI:	10.1017/S0031182019000192
Open Access URL:	https://doi.org/10.1017/S0031182019000192
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3032235