Bullseye's representation of cerebral white matter hyperintensities


Sudre, CH, Anson, B Gomez, Davagnanam, I, Schmitt, A, Mendelson, AF, Prados, F, Smith, L, Atkinson, D, Hughes, AD ORCID: 0000-0001-5432-5271, Chaturvedi, N et al (show 4 more authors) (2018) Bullseye's representation of cerebral white matter hyperintensities. JOURNAL OF NEURORADIOLOGY, 45 (2). pp. 114-122.

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Abstract

<h4>Background and purpose</h4>Visual rating scales have limited capacities to depict the regional distribution of cerebral white matter hyperintensities (WMH). We present a regional-zonal volumetric analysis alongside a visualization tool to compare and deconstruct visual rating scales.<h4>Materials and methods</h4>3D T1-weighted, T2-weighted spin-echo and FLAIR images were acquired on a 3T system, from 82 elderly participants in a population-based study. Images were automatically segmented for WMH. Lobar boundaries and distance to ventricular surface were used to define white matter regions. Regional-zonal WMH loads were displayed using bullseye plots. Four raters assessed all images applying three scales. Correlations between visual scales and regional WMH as well as inter and intra-rater variability were assessed. A multinomial ordinal regression model was used to predict scores based on regional volumes and global WMH burdens.<h4>Results</h4>On average, the bullseye plot depicted a right-left symmetry in the distribution and concentration of damage in the periventricular zone, especially in frontal regions. WMH loads correlated well with the average visual rating scores (e.g. Kendall's tau [Volume, Scheltens]=0.59 CI=[0.53 0.62]). Local correlations allowed comparison of loading patterns between scales and between raters. Regional measurements had more predictive power than global WMH burden (e.g. frontal caps prediction with local features: ICC=0.67 CI=[0.53 0.77], global volume=0.50 CI=[0.32 0.65], intra-rater=0.44 CI=[0.23 0.60]).<h4>Conclusion</h4>Regional-zonal representation of WMH burden highlights similarities and differences between visual rating scales and raters. The bullseye infographic tool provides a simple visual representation of regional lesion load that can be used for rater calibration and training.

Item Type: Article
Uncontrolled Keywords: White matter hyper intensities, Visual rating scales, Magnetic resonance imaging, Location, Ageing
Depositing User: Symplectic Admin
Date Deposited: 07 Feb 2019 11:49
Last Modified: 19 Jan 2023 01:05
DOI: 10.1016/j.neurad.2017.10.001
Open Access URL: https://doi.org/10.1016/j.neurad.2017.10.001
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3032439
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