Constituents of the Roots of <i>Dichapetalum pallidum</i> and Their Anti-Proliferative Activity

Osei-Safo, Dorcas, Dziwornu, Godwin Akpeko, Appiah-Opong, Regina, Chama, Mary Anti, Tuffour, Isaac, Waibel, Reiner, Amewu, Richard ORCID: 0000-0002-4676-436X and Addae-Mensah, Ivan
(2017) Constituents of the Roots of <i>Dichapetalum pallidum</i> and Their Anti-Proliferative Activity. MOLECULES, 22 (4). E532-.

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As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, <i>Dichapetalum pallidum</i>, led to the isolation of the newly occurring 7-hydroxydichapetalin P (<b>1</b>) and the known dichapetalins A (<b>2</b>) and X (<b>3</b>). Also isolated were the known compounds friedelin-2,3-lactone (<b>4</b>), friedelan-3-one (<b>6</b>), friedelan-3β-ol (<b>7</b>) and pomolic (<b>8</b>), as well as the dipeptide aurantiamide acetate (<b>5</b>). The compounds were characterized by direct interpretation of their IR, 1D NMR and 2D NMR spectral data and by comparison of their physico-chemical data, including their chromatographic profiles, with the literature and authentic samples in our compound library for the genus <i>Dichapetalum</i>. The compounds were assayed for their anti-proliferative activities against the human T-lymphocytic leukemia (Jurkat), acute promyelocytic leukemia (HL-60) and T-lymphoblast-like leukemia (CEM) cell lines. Overall, dichapetalin X showed the strongest (3.14 μM) and broadest cytotoxic activities against all the leukemic cell lines tested, exhibiting even stronger activities than the standard compound, curcumin.

Item Type: Article
Uncontrolled Keywords: Dichapetalum pallidum, 7-hydroxydichapetalin P, dichapetalin A, dichapetalin X, spiroketal, leukemia
Depositing User: Symplectic Admin
Date Deposited: 07 Feb 2019 14:59
Last Modified: 13 Feb 2024 14:08
DOI: 10.3390/molecules22040532
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