Nonstructural Proteins of AlphavirusPotential Targets for Drug Development

Abu Bakar, Farhana and Ng, Lisa FP ORCID: 0000-0003-4071-5222 (2018) Nonstructural Proteins of AlphavirusPotential Targets for Drug Development. VIRUSES-BASEL, 10 (2). E71-.

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Official URL: http://dx.doi.org/10.3390/v10020071

Abstract

Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available. The re-emergence of alphaviruses in Asia, Europe, and the Americas over the last decade, including chikungunya and o'nyong'nyong viruses, have intensified the search for selective inhibitors. In this review, we highlight key molecular determinants within the alphavirus replication complex that have been identified as viral targets, focusing on their structure and functionality in viral dissemination. We also summarize recent structural data of these viral targets and discuss how these could serve as templates to facilitate structure-based drug design and development of small molecule inhibitors.

Item Type:	Article
Uncontrolled Keywords:	alphavirus replication, nonstructural protein, protease inhibitors
Depositing User:	Symplectic Admin
Date Deposited:	11 Feb 2019 11:49
Last Modified:	01 Feb 2024 05:45
DOI:	10.3390/v10020071
Open Access URL:	http://doi.org/10.3390/v10020071
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3032640