Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance.

Park, Chloe, Fraser, Abigail, Howe, Laura D, Jones, Siana, Davey Smith, George, Lawlor, Debbie A, Chaturvedi, Nish and Hughes, Alun D ORCID: 0000-0001-5432-5271 (2018) Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance. Hypertension (Dallas, Tex. : 1979), 72 (5). pp. 1103-1108.

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Official URL: http://dx.doi.org/10.1161/hypertensionaha.118.1192...

Abstract

Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)-a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)-a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%-34%], HR [25%-29%], and TPR [39%-41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels.

Item Type:	Article
Uncontrolled Keywords:	Humans, Hypertension, Blood Pressure Determination, Cardiac Output, Stroke Volume, Longitudinal Studies, Blood Pressure, Heart Rate, Vascular Resistance, Adolescent, Female, Male
Depositing User:	Symplectic Admin
Date Deposited:	12 Feb 2019 10:41
Last Modified:	19 Jan 2023 01:04
DOI:	10.1161/HYPERTENSIONAHA.118.11925
Open Access URL:	https://doi.org/10.1161/HYPERTENSIONAHA.118.11925
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3032713