Kam, Yiu-Wing, Leite, Juliana Almeida, Lum, Fok-Moon, Tan, Jeslin JL, Lee, Bernett, Judice, Carla C, de Toledo Teixeira, Daniel Augusto, Andreata-Santos, Robert, Vinolo, Marco A, Angerami, Rodrigo et al (show 13 more authors)
(2017)
Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil.
JOURNAL OF INFECTIOUS DISEASES, 216 (2).
pp. 172-181.
Abstract
<h4>Background</h4>Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations.<h4>Methods</h4>We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas, Brazil. These patients included 6 pregnant women who later delivered during the course of this study. Clinical observations were recorded during hospitalization. Levels of 45 immune mediators were quantified using multiplex microbead-based immunoassays.<h4>Results</h4>Whereas 11.6% of patients had neurological complications, 88.4% displayed mild disease of rash and fever. Several immune mediators were specifically higher in ZIKV-infected patients, and levels of interleukin 10, interferon gamma-induced protein 10 (IP-10), and hepatocyte growth factor differentiated between patients with or without neurological complications. Interestingly, higher levels of interleukin 22, monocyte chemoattractant protein 1, TNF-α, and IP-10 were observed in ZIKV-infected pregnant women carrying fetuses with fetal growth-associated malformations. Notably, infants with congenital central nervous system deformities had significantly higher levels of interleukin 18 and IP-10 but lower levels of hepatocyte growth factor than those without such abnormalities born to ZIKV-infected mothers.<h4>Conclusions</h4>This study identified several key markers for the control of ZIKV pathogenesis. This will allow a better understanding of the molecular mechanisms of ZIKV infection in patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Zika virus, congenital CNS deformities, cytokines and biomarkers |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Feb 2019 10:53 |
| Last Modified: | 19 Jan 2023 01:03 |
| DOI: | 10.1093/infdis/jix261 |
| Open Access URL: | http://doi.org/10.1093/infdis/jix261 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3032835 |
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