The effect of <i>Banisteriopsis caapi</i> (<i>B.caapi</i>) on the motor deficits in the MPTP-treated common marmoset model of Parkinson's disease

Fisher, Ria, Lincoln, Louise, Jackson, Michael J, Abbate, Vincenzo, Jenner, Peter, Hider, Robert, Lees, Andrew ORCID: 0000-0002-2476-4385 and Rose, Sarah
(2018) The effect of <i>Banisteriopsis caapi</i> (<i>B.caapi</i>) on the motor deficits in the MPTP-treated common marmoset model of Parkinson's disease. PHYTOTHERAPY RESEARCH, 32 (4). pp. 678-687.

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Banisteriopsis caapi (B. caapi) contains harmine, harmaline, and tetrahydroharmine, has monoamine oxidase inhibitory activity, and has reported antiparkinsonian activity in humans when imbibed as a tea; however, its effects are poorly documented. For this reason, motor function was assessed in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets following administration of B. caapi extract (28.4-113.6 mg/kg; po), harmine (0.1 and 0.3 mg/kg; sc), and selegiline (10 mg/kg; sc), alone or with a submaximal dose of L-3,4-dihydroxyphenylalanine (L-DOPA; 4-7 mg/kg). L-DOPA reversed motor disability, increased locomotor activity, and induced moderate dyskinesia. B. caapi did not increase locomotor activity or induce dyskinesia but at 56.8 and 113.6 mg/kg improved motor disability. The L-DOPA response was unaltered by co-administration of B. caapi. Harmine (0.1 and 0.3 mg/kg) produced a mild improvement in motor disability without affecting locomotor activity or dyskinesia but had no effect on the L-DOPA-induced antiparkinsonian response. Selegiline (10 mg/kg) alone improved motor function to the same extent as L-DOPA, but with only mild dyskinesia, and did not alter the response to L-DOPA, although dyskinesia was reduced. The findings suggest that B. caapi alone has a mild antiparkinsonian effect but does not enhance the L-DOPA response or reduce dyskinesia.

Item Type: Article
Additional Information: publicationstatus: published
Uncontrolled Keywords: Banisteriopsis, monoamine oxidase, MPTP, Parkinson's disease, primate
Depositing User: Symplectic Admin
Date Deposited: 14 Feb 2019 11:58
Last Modified: 14 Oct 2023 09:22
DOI: 10.1002/ptr.6017
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