What proportion of AQP4-IgG-negative NMO spectrum disorder patients are MOG-IgG positive? A cross sectional study of 132 patients



Hamid, Shahd HM, Whittam, Daniel, Mutch, Kerry, Linaker, Samantha, Solomon, Tom ORCID: 0000-0001-7266-6547, Das, Kumar, Bhojak, Maneesh and Jacob, Anu
(2017) What proportion of AQP4-IgG-negative NMO spectrum disorder patients are MOG-IgG positive? A cross sectional study of 132 patients. JOURNAL OF NEUROLOGY, 264 (10). pp. 2088-2094.

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Abstract

Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been described in patients with neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 antibodies (AQP4-IgG). We aimed to identify the proportion of AQP4-IgG-negative NMOSD patients who are seropositive for MOG-IgG. In a cross sectional study, we reviewed all patients seen in the National NMO clinic over the last 4 years (after the availability of MOG-IgG testing), including clinical information, MRI, and antibody tests. 261 unique patients were identified. 132 cases satisfied the 2015 NMOSD diagnostic criteria. Of these, 96 (73%) were AQP4-IgG positive and 36 (27%) were AQP4-IgG negative. These 36 patients were tested for MOG-IgG and 15/36 (42%) tested positive. 20% (25/125) of the patients who did not satisfy NMOSD criteria had MOG-IgG. Approximately half of seronegative NMOSD is MOG-Ig seropositive and one in five of non-NMOSD/non-MS demyelination is MOG-IgG positive. Since MOG-associated demyelinating disease is likely different from AQP4-IgG disease in terms of underlying disease mechanisms, relapse risk and possibly treatment, testing for MOG-IgG in patients with AQP4-IgG-negative NMOSD and other non-MS demyelination may have significant implications to management and clinical trials.

Item Type: Article
Uncontrolled Keywords: Neuromyelitis optica, Aquaporin-4 antibodies, Myelin oligodendrocytes glycoprotein
Depositing User: Symplectic Admin
Date Deposited: 18 Feb 2019 10:02
Last Modified: 19 Jan 2023 01:03
DOI: 10.1007/s00415-017-8596-7
Open Access URL: http://doi.org/10.1007/s00415-017-8596-7
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3032906