Aberrant redox signalling and stress response in age-related muscle decline: Role in inter- and intra-cellular signalling

McArdle, Anne, Pollock, Natalie ORCID: 0000-0002-4969-5486, Staunton, Caroline A ORCID: 0000-0003-0647-3063 and Jackson, Malcolm J ORCID: 0000-0003-3683-8297
(2019) Aberrant redox signalling and stress response in age-related muscle decline: Role in inter- and intra-cellular signalling. FREE RADICAL BIOLOGY AND MEDICINE, 132. pp. 50-57.

Access the full-text of this item by clicking on the Open Access link.


Age-associated frailty is predominantly due to loss of muscle mass and function. The loss of muscle mass is also associated with a greater loss of muscle strength, suggesting that the remaining muscle fibres are weaker than those of adults. The mechanisms by which muscle is lost with age are unclear, but in this review we aim to pull together various strands of evidence to explain how muscle contractions support proteostasis in non-muscle tissues, particularly focussed on the production and potential transfer of Heat Shock Proteins (HSPs) and how this may fail during ageing, Furthermore we will identify logical approaches, based on this hypothesis, by which muscle loss in ageing may be reduced. Skeletal muscle generates superoxide and nitric oxide at rest and this generation is increased by contractile activity. In adults, this increased generation of reactive oxygen and nitrogen species (RONS) activate redox-sensitive transcription factors such as nuclear factor κB (NFκB), activator protein-1 (AP1) and heat shock factor 1 (HSF1), resulting in increases in cytoprotective proteins such as the superoxide dismutases, catalase and heat shock proteins that prevent oxidative damage to tissues and facilitate remodelling and proteostasis in both an intra- and inter-cellular manner. During ageing, the ability of skeletal muscle from aged organisms to respond to an increase in ROS generation by increased expression of cytoprotective proteins through activation of redox-sensitive transcription factors is severely attenuated. This age-related lack of physiological adaptations to the ROS induced by contractile activity appears to contribute to a loss of ROS homeostasis, increased oxidative damage and age-related dysfunction in skeletal muscle and potentially other tissues.

Item Type: Article
Uncontrolled Keywords: Skeletal muscle, Aging, ROS, HSPs, Exosomes, NMJ
Depositing User: Symplectic Admin
Date Deposited: 29 Jan 2020 08:39
Last Modified: 19 Jan 2023 01:02
DOI: 10.1016/j.freeradbiomed.2018.11.038
Open Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC67096...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3033090