Submaximal exercise blood pressure and cardiovascular structure in adolescence.

Schultz, Martin G, Park, Chloe, Fraser, Abigail, Howe, Laura D, Jones, Siana, Rapala, Alicja, Davey Smith, George, Sharman, James E, Lawlor, Deborah A, Chaturvedi, Nish
et al (show 2 more authors) (2018) Submaximal exercise blood pressure and cardiovascular structure in adolescence. International journal of cardiology, 275. pp. 152-157.

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PURPOSE:Dynamic exercise results in increased systolic blood pressure (BP). Irrespective of resting BP, some individuals may experience exaggerated rise in systolic BP with exercise, which in adulthood is associated with risk of hypertension, and cardiovascular (CV) disease. It is unknown if exercise BP is associated with markers of CV structure during adolescence. We examined this question in a large adolescent cohort taking account of the possible confounding effect of body composition and BP status. METHODS:4036 adolescents (mean age 17.8 ± 0.4 years, 45% male), part of a UK population-based birth cohort study completed a sub-maximal step-test with BP immediately post-exercise. Sub-samples underwent comprehensive echocardiography for assessment of cardiac structure; arterial structure including aortic pulse wave velocity (PWV) and carotid intima-media thickness; and assessment of body composition by dual-energy X-ray absorptiometry (DXA). RESULTS:Each 5 mm Hg higher post-exercise systolic BP was associated with CV structure, including 0.38 g/m2.7 (95% CI: 0.29, 0.47) greater left-ventricular mass index (LVMI), and 0.04 m/s (95% CI: 0.03, 0.04) greater aortic PWV. Adjustment for age, total body fat, lean mass and BP status attenuated, but did not abolish associations with LVMI (0.14 g/m2.7 per 5 mm Hg of post-exercise systolic BP; 95% CI 0.21, 0.39) or aortic PWV (0.03 m/s per 5 mm Hg of post-exercise systolic BP; 95% CI: 0.02, 0.04). CONCLUSION:Submaximal exercise systolic BP is associated with markers of CV structure in adolescents. Given the clinical relevance of exercise BP in adulthood, such associations may have implications for CV disease screening in young people and risk in later life.

Item Type: Article
Uncontrolled Keywords: Cardiovascular System, Humans, Cardiovascular Diseases, Echocardiography, Prognosis, Follow-Up Studies, Prospective Studies, Cross-Sectional Studies, Reproducibility of Results, Predictive Value of Tests, Body Composition, Blood Pressure, Exercise Tolerance, Adolescent, Female, Male, Carotid Intima-Media Thickness, Vascular Stiffness, Pulse Wave Analysis
Depositing User: Symplectic Admin
Date Deposited: 28 Feb 2019 11:59
Last Modified: 19 Jan 2023 01:00
DOI: 10.1016/j.ijcard.2018.10.060
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