Etiology of Diarrhea Among Hospitalized Children in Blantyre, Malawi, Following Rotavirus Vaccine Introduction: A Case-Control Study


Iturriza-Gomara, Miren ORCID: 0000-0001-5816-6423, Jere, KC ORCID: 0000-0003-3376-8529, Hungerford, DJ ORCID: 0000-0002-9770-0163, Bar-Zeev, NH ORCID: 0000-0003-0570-4624, Shioda, Kayoko, Kanjerwa, Oscar, Houpt, Eric, Operario, Darwin J, Wachepa, Richard, Pollock, Louisa et al (show 3 more authors) (2019) Etiology of Diarrhea Among Hospitalized Children in Blantyre, Malawi, Following Rotavirus Vaccine Introduction: A Case-Control Study. Journal of Infectious Diseases, 220 (2). pp. 213-218.

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Abstract

Despite rotavirus vaccination, diarrhea remains a leading cause of child mortality. We collected stool specimens from 684 children <5 years of age hospitalized with diarrhea (cases) and 527 asymptomatic community controls for 4 years after rotavirus vaccine introduction in Malawi. Specimens were tested for 29 pathogens, using polymerase chain reaction analysis. Three or more pathogens were detected in 71% of cases and 48% of controls. Pathogens significantly associated with diarrhea included rotavirus (in 34.7% of cases and 1.5% of controls), enteric adenovirus (in 29.1% and 2.7%, respectively), Cryptosporidium (in 27.8% and 8.2%, respectively), heat-stable enterotoxin-producing Escherichia coli (in 21.2% and 8.5%, respectively), typical enteropathogenic E. coli (in 18.0% and 8.3%, respectively), and Shigella/enteroinvasive E. coli (in 15.8% and 5.7%, respectively). Additional interventions are required to prevent diarrhea due to rotavirus and other common causal pathogens.

Item Type: Article
Uncontrolled Keywords: Gastroenteritis, diarrhea, children, PCR, rotavirus, case-control, Malawi
Depositing User: Symplectic Admin
Date Deposited: 05 Mar 2019 09:13
Last Modified: 19 Jan 2023 01:00
DOI: 10.1093/infdis/jiz084
Open Access URL: https://doi.org/10.1093/infdis/jiz084
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3033627
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