Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD.



Zhang, Baihua, Qi, Shouliang, Yue, Yong ORCID: 0000-0001-7695-4538, Shen, Jing, Li, Chen, Qian, Wei and Wu, Jianlin
(2018) Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD. BioMed research international, 2018. 7428609 - 7428609.

Access the full-text of this item by clicking on the Open Access link.

Abstract

Dispositions of inhalable particles in the human respiratory tract trigger and exacerbate airway inflammatory diseases. However, the particle deposition (PD) in airway of subjects with tracheal bronchus (TB) and chronic obstructive pulmonary diseases (COPD) is unknown. We therefore propose to clarify the disrupted PD associated with TB and COPD using the computational fluid dynamics (CFD) simulation. Totally nine airway tree models are included. Six are extracted from CT images of different individuals (two with TB, two with COPD, and two healthy controls (HC)). The others are the artificially modified models (AMMs) generated by the virtual lesion. Specifically, they are constructed through artificially adding a tracheal bronchus or a stenosis on one HC model. The deposition efficiency (DE) and deposition fraction (DF) in these models are obtained by the Euler-Lagrange approach, analyzed, and compared across models, locations, and particle sizes (0.1-10.0 micrometers). It is found that the PD in models with TB and COPD has been disrupted by the geometrical changes and followed airflow alternations. DE of the tracheal bronchus is higher for TB models. For COPD, the stenosis location determines the effects on DE and DF. Higher DF at the trachea is observed in TB1, TB2, and COPD2 models. DE increases with the particle size, and DE of the terminal bronchi is higher than that of central regions. Combined with AMMs, the CFD simulation using realistic airway models demonstrates disruptions of DP. The methods and findings might help understand the etiology of pulmonary diseases and improve the efficacy of inhaled medicines.

Item Type: Article
Uncontrolled Keywords: Bronchi, Trachea, Humans, Pulmonary Disease, Chronic Obstructive, Particle Size, Models, Biological, Adult, Aged, Middle Aged, China, Belgium, Female, Male
Depositing User: Symplectic Admin
Date Deposited: 06 Mar 2019 11:18
Last Modified: 02 Sep 2022 05:10
DOI: 10.1155/2018/7428609
Open Access URL: https://doi.org/10.1155/2018/7428609
URI: https://livrepository.liverpool.ac.uk/id/eprint/3033850