Actissist: Proof-of-Concept Trial of a Theory-Driven Digital Intervention for Psychosis.



Bucci, Sandra, Barrowclough, Christine, Ainsworth, John, Machin, Matthew, Morris, Rohan, Berry, Katherine ORCID: 0000-0002-7399-5462, Emsley, Richard ORCID: 0000-0002-1218-675X, Lewis, Shon, Edge, Dawn, Buchan, Iain ORCID: 0000-0003-3392-1650
et al (show 1 more authors) (2018) Actissist: Proof-of-Concept Trial of a Theory-Driven Digital Intervention for Psychosis. Schizophrenia bulletin, 44 (5). 1070 - 1080.

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Abstract

<h4>Background</h4>Timely access to intervention for psychosis is crucial yet problematic. As such, health care providers are forming digital strategies for addressing mental health challenges. A theory-driven digital intervention that monitors distressing experiences and provides real-time active management strategies could improve the speed and quality of recovery in psychosis, over and above conventional treatments. This study assesses the feasibility and acceptability of Actissist, a digital health intervention grounded in the cognitive model of psychosis that targets key early psychosis domains.<h4>Methods</h4>A proof-of-concept, single, blind, randomized controlled trial of Actissist, compared to a symptom-monitoring control. Thirty-six early psychosis patients were randomized on a 2:1 ratio to each arm of the trial. Actissist was delivered via a smartphone app over 12-weeks; clinical and functional assessment time-points were baseline, post-treatment and 22-weeks. Assessors' blind to treatment condition conducted the assessments. Acceptability was examined using qualitative methods.<h4>Results</h4>Actissist was feasible (75% participants used Actissist at least once/day; uptake was high, 97% participants remained in the trial; high follow-up rates), acceptable (90% participants recommend Actissist), and safe (0 serious adverse events), with high levels of user satisfaction. Treatment effects were large on negative symptoms, general psychotic symptoms and mood. The addition of Actissist conferred benefit at post-treatment assessment over routine symptom-monitoring and treatment as usual.<h4>Conclusions</h4>This is the first controlled proof-of-concept trial of a theory-driven digital health intervention for early psychosis. Actissist is feasible and acceptable to early psychosis patients, with a strong signal for treatment efficacy. Trial Registration: ISRCTN: 34966555.

Item Type: Article
Uncontrolled Keywords: Humans, Feasibility Studies, Pilot Projects, Single-Blind Method, Psychotic Disorders, Behavior Therapy, Telemedicine, Adolescent, Adult, Patient Acceptance of Health Care, Female, Male, Young Adult, Mobile Applications, Proof of Concept Study, Outcome and Process Assessment, Health Care
Depositing User: Symplectic Admin
Date Deposited: 26 Mar 2019 14:01
Last Modified: 09 May 2021 07:18
DOI: 10.1093/schbul/sby032
Open Access URL: https://doi.org/10.1093/schbul/sby055
URI: https://livrepository.liverpool.ac.uk/id/eprint/3034983