Thaventhiran, Thilipan, Wong, Wai, Alghanem, Ahmad F, Alhumeed, Naif 
ORCID: 0000-0001-5221-3073, Aljasir, Mohammad A, Ramsey, Simeon, Sethu, Swaminathan ORCID: 0000-0001-9210-2554, Yeang, Han Xian Aw, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Cross, Michael ORCID: 0000-0002-5533-1232 et al (show 5 more authors)
(2019)
CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 38 (2).
pp. 60-69.
ISSN 2167-9436, 2167-9436
Abstract
CD28 superagonist (CD28SA), a therapeutic immunomodulatory monoclonal antibody triggered rapid and exaggerated activation of CD4<sup>+</sup> effector memory T cells (T<sub>EMs</sub>) in humans with unwanted serious adverse effects. It is well known that distinct metabolic programs determine the fate and responses of immune cells. In this study, we show that human CD4<sup>+</sup> T<sub>EMs</sub> stimulated with CD28SA adopt a metabolic program similar to those of tumor cells with enhanced glucose utilization, lipid biosynthesis, and proliferation in hypoxic conditions. Identification of metabolic profiles underlying hyperactive T cell activation would provide a platform to test safety of immunostimulatory antibodies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD4-Positive T-Lymphocytes, Tumor Cells, Cultured, Humans, Neoplasms, Acetyl Coenzyme A, Protein Kinases, Glucose, Antibodies, Monoclonal, Lymphocyte Activation, Cell Proliferation, Immunologic Memory, Glycolysis, Lipogenesis, T-Lymphocytes, Regulatory, CD28 Antigens |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 29 Apr 2019 11:04 |
| Last Modified: | 07 Dec 2024 06:54 |
| DOI: | 10.1089/mab.2018.0042 |
| Open Access URL: | https://www.liebertpub.com/doi/10.1089/mab.2018.00... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3038882 |
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