Comparative immunohistochemical and molecular investigations of metabolic and stromal events in HPV positive and HPV negative oropharyngeal squamous cell carcinoma


Ben Salah, KS (2018) Comparative immunohistochemical and molecular investigations of metabolic and stromal events in HPV positive and HPV negative oropharyngeal squamous cell carcinoma Doctor of Philosophy thesis, University of Liverpool.

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Abstract

Background: It has been shown that HPV positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) are characterised by extensive nodal disease, but are associated with significantly better prognosis than HPV negative (HPV-) OPSCC. It has also been proposed that glycosaminoglycans (GAGs) and myofibroblasts are components of the desmoplastic stroma that characterizes many advanced carcinomas. They are considered to play an important role in the pathogenesis of head and neck squamous cell carcinomas (HNSCC) and their presence is of high prognostic value. A 'three compartment tumour metabolism' model has been proposed in head and neck cancer comprising a proliferative, monocarboxylate transporter1 (MCT1)-expressing carcinoma cell population at the tumour advancing front (front) with both a deeper population of monocarboxylate transporter 4 (MCT4)+ cancer cells and (MCT4)+ cancer associated fibroblasts (CAFs) providing a source of metabolic fuels via a lactate shuttle. This thesis investigates the presence and distribution of GAGs and myofibroblasts in HPV+ and HPV- OPSCC, and their correlation with clinicopathological features. We also investigate the metabolic activities of OPSCC in relation to HPV status. ... (continues)

Item Type: Thesis (Doctor of Philosophy)
Divisions: Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > School of Medicine
Depositing User: Symplectic Admin
Date Deposited: 21 Aug 2019 14:47
Last Modified: 02 Nov 2024 12:36
DOI: 10.17638/03038990
Supervisors:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3038990
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