Donnellan, Samantha, Stone, Vicki, Johnston, Helinor, Giardiello, Marco 
ORCID: 0000-0003-0560-4711, Owen, Andrew ORCID: 0000-0002-9819-7651, Rannard, Steve ORCID: 0000-0002-6946-1097, Aljayyoussi, Ghaith, Swift, Benjamin, Tran, Lang, Watkins, Craig et al (show 1 more authors)
(2017)
Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity.
Journal of Interdisciplinary Nanomedicine, 2 (3).
pp. 146-156.
Abstract
<jats:title>Abstract</jats:title><jats:p>Tuberculosis kills more people worldwide than any other infectious disease. Treatment requires multiple drug therapy administered over long periods (6–24 months). The emergence of multidrug‐resistant strains is a major problem, and with few new drugs in the pipeline, a novel modus operandi is urgently required. Solid drug nanoparticles (SDNs), a new development in nanomedicine, offer a fresh therapeutic approach. Here, we show that SDNs are more effective (50‐fold) at killing pathogenic mycobacteria than aqueous forms of the same drug and can target mycobacteria internalised by macrophages, where bacilli reside. We demonstrate synthesis of dual and triple drug loaded SDNs, facilitating combination tuberculosis therapy. Our results suggest that by employing SDNs of existing antibiotics, it may be possible to improve drug delivery and therefore reduce drug dosage to lessen side effects and fight drug resistance.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Infectious Diseases, Rare Diseases, Antimicrobial Resistance, Orphan Drug, Tuberculosis, HIV/AIDS, Biotechnology, Nanotechnology, Bioengineering, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions, 6 Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, 3 Good Health and Well Being |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 May 2019 09:53 |
| Last Modified: | 11 Apr 2024 18:23 |
| DOI: | 10.1002/jin2.27 |
| Open Access URL: | https://doi.org/10.1002/jin2.27 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3040038 |
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