Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity


Donnellan, Samantha, Stone, Vicki, Johnston, Helinor, Giardiello, Marco ORCID: 0000-0003-0560-4711, Owen, Andrew ORCID: 0000-0002-9819-7651, Rannard, Steve ORCID: 0000-0002-6946-1097, Aljayyoussi, Ghaith, Swift, Benjamin, Tran, Lang, Watkins, Craig et al (show 1 more authors) (2017) Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity Journal of Interdisciplinary Nanomedicine, 2 (3). pp. 146-156. ISSN 2058-3273, 2058-3273

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Abstract

AbstractTuberculosis kills more people worldwide than any other infectious disease. Treatment requires multiple drug therapy administered over long periods (6–24 months). The emergence of multidrug‐resistant strains is a major problem, and with few new drugs in the pipeline, a novel modus operandi is urgently required. Solid drug nanoparticles (SDNs), a new development in nanomedicine, offer a fresh therapeutic approach. Here, we show that SDNs are more effective (50‐fold) at killing pathogenic mycobacteria than aqueous forms of the same drug and can target mycobacteria internalised by macrophages, where bacilli reside. We demonstrate synthesis of dual and triple drug loaded SDNs, facilitating combination tuberculosis therapy. Our results suggest that by employing SDNs of existing antibiotics, it may be possible to improve drug delivery and therefore reduce drug dosage to lessen side effects and fight drug resistance.

Item Type: Article
Uncontrolled Keywords: 3206 Medical Biotechnology, 32 Biomedical and Clinical Sciences, Nanotechnology, Biotechnology, Bioengineering, Infectious Diseases, Orphan Drug, Biodefense, Antimicrobial Resistance, Emerging Infectious Diseases, Tuberculosis, Rare Diseases, 5.1 Pharmaceuticals, Infection, 3 Good Health and Well Being
Depositing User: Symplectic Admin
Date Deposited: 07 May 2019 09:53
Last Modified: 04 Dec 2025 19:14
DOI: 10.1002/jin2.27
Open Access URL: https://doi.org/10.1002/jin2.27
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3040038
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