A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab®.



Stader, Felix, Penny, Melissa A, Siccardi, Marco ORCID: 0000-0002-3539-7867 and Marzolini, Catia
(2019) A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab®. CPT: pharmacometrics & systems pharmacology.

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Abstract

Physiologically based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole-body PBPK model in Matlab® to answer specific pharmacological questions involving drug disposition, and magnitudes of drug-drug interactions in different patient populations. This article is protected by copyright. All rights reserved.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 10 May 2019 08:52
Last Modified: 29 Dec 2021 20:10
DOI: 10.1002/psp4.12399
Open Access URL: https://doi.org/10.1002/psp4.12399
URI: https://livrepository.liverpool.ac.uk/id/eprint/3040578