Duffy, Fergal J, Thompson, Ethan, Downing, Katrina, Suliman, Sara, Mayanja-Kizza, Harriet, Boom, W Henry, Thiel, Bonnie, Weiner, January, Kaufmann, Stefan HE, Dover, Drew et al (show 8 more authors)
(2018)
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts.
FRONTIERS IN IMMUNOLOGY, 9 (APR).
661-.
Abstract
Biomarkers that predict who among recently <i>Mycobacterium tuberculosis</i> (MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and circulating miRNAs (c-miRNAs) have been developed as biomarkers for other diseases. We performed machine-learning analysis of c-miRNA measurements in the serum of adult household contacts (HHCs) of TB index cases from South Africa and Uganda and developed a c-miRNA-based signature of risk for progression to active TB. This c-miRNA-based signature significantly discriminated HHCs within 6 months of progression to active disease from HHCs that remained healthy in an independent test set [ROC area under the ROC curve (AUC) 0.74, progressors < 6 Mo to active TB and ROC AUC 0.66, up to 24 Mo to active TB], and complements the predictions of a previous cellular mRNA-based signature of TB risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | tuberculosis, microRNA, household contact, biomarker, correlate of risk, machine learning |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 May 2019 08:03 |
| Last Modified: | 02 Feb 2024 15:39 |
| DOI: | 10.3389/fimmu.2018.00661 |
| Open Access URL: | https://doi.org/10.3389/fimmu.2018.00661 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3040972 |
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