Silvester, Alexander, Neal, Timothy, Czanner, Gabriela, Briggs, Michael, Harding, Simon 
ORCID: 0000-0003-4676-1158 and Kaye, Stephen ORCID: 0000-0003-0390-0592
(2016)
Adult bacterial conjunctivitis: resistance patterns over 12 years in patients attending a large primary eye care centre in the UK.
BMJ OPEN OPHTHALMOLOGY, 1 (1).
e000006-.
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Adult bacterial conjunctivitis: resistance patterns over 12 years in patients attending a large primary eye care centre in the UK.pdf - Published version Download (302kB) | Preview |
Abstract
<h4>Purpose</h4>To determine whether there was a change in the resistance pattern of bacteria isolated from cases of conjunctivitis following the introduction of over-the-counter availability of chloramphenicol in 2005.<h4>Design and setting</h4>Retrospective review of laboratory records for adult patients with suspected bacterial conjunctivitis between 2001 and 2012 attending the Royal Liverpool University Hospital.<h4>Participants</h4>Patients with suspected bacterial conjunctivitis. Organisms were identified by standard laboratory methods. Scanty growth and normal flora were considered as a negative result. For positive results, susceptibility testing was undertaken as per British Society for Antimicrobial Chemotherapy guidelines.<h4>Main outcome measures</h4>Prevalence of groups of bacteria associated with acute conjunctivitis and their resistance to chloramphenicol, ciprofloxacin, gentamicin, and methicillin.<h4>Results</h4>A total of 8209 conjunctival swabs were reviewed; 1300 (15.8%) were considered positive, of which 977 (75.2%) and 323 (24.8%) bacteria were identified as Gram positive and Gram negative, respectively. <i>Staphylococcus aureus</i> was the most prevalent organism identified. Resistance of all bacterial isolates to chloramphenicol was 8.4% varying from 3.0% to 16.4% while that for ciprofloxacin and gentamicin was 16.4% and 14.0%, respectively. Methicillin resistance among <i>S. aureus</i> was 8.3%.<h4>Conclusion</h4>Resistance to chloramphenicol has remained stable since being made available over the counter. Among Gram-positive bacteria, the most prevalent causative agent of bacterial conjunctivitis, chloramphenicol sensitivity remains high.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MRSA, conjunctivitis chloramphenicol resistance |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 May 2019 08:20 |
| Last Modified: | 19 Jan 2023 00:46 |
| DOI: | 10.1136/bmjophth-2016-000006 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3040982 |
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