Augustin, Hrvoje 
ORCID: 0000-0002-2041-3844, McGourty, Kieran, Allen, Marcus J, Adcott, Jennifer ORCID: 0000-0001-9146-3171, Wong, Chi Tung, Boucrot, Emmanuel ORCID: 0000-0001-7312-6462 and Partridge, Linda ORCID: 0000-0001-9615-0094
(2018)
Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster.
Neurobiology of aging, 66.
pp. 149-157.
ISSN 0197-4580, 1558-1497
Abstract
The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Neurons, Cells, Cultured, Animals, Drosophila melanogaster, Proteasome Endopeptidase Complex, Insulin, GTP Phosphohydrolases, rab GTP-Binding Proteins, Intercellular Signaling Peptides and Proteins, Somatomedins, Drosophila Proteins, Signal Transduction, Synaptic Transmission, Aging, Longevity |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 15 May 2019 09:16 |
| Last Modified: | 07 Dec 2024 20:56 |
| DOI: | 10.1016/j.neurobiolaging.2018.02.027 |
| Open Access URL: | https://doi.org/10.1016/j.neurobiolaging.2018.02.0... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3041414 |
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