Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens



Rickman, J, Tronci, G, Liang, H ORCID: 0000-0002-7361-4690 and Russell, SJ
(2019) Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens. Journal of Materials Science, 54 (14). 10529 - 10547.

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Abstract

© 2019, The Author(s). Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 16 May 2019 09:23
Last Modified: 30 Mar 2021 14:14
DOI: 10.1007/s10853-019-03498-5
Open Access URL: https://doi.org/10.1007/s10853-019-03498-5
URI: https://livrepository.liverpool.ac.uk/id/eprint/3041587