Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial



Rowe, Fiona J ORCID: 0000-0001-9210-9131, Hepworth, Lauren R ORCID: 0000-0001-8542-9815, Conroy, Elizabeth J ORCID: 0000-0003-4858-727X, Rainford, Naomi EA, Bedson, Emma, Drummond, Avril, Garcia-Finana, Marta, Howard, Claire, Pollock, Alex, Shipman, Tracey
et al (show 4 more authors) (2019) Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial. Eye, 33 (9). 1485 - 1493.

[img] Text
29010_1_merged_1554458063.pdf - Accepted Version

Download (493kB) | Preview

Abstract

Background: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.

Item Type: Article
Uncontrolled Keywords: eye manifestations, quality of life
Depositing User: Symplectic Admin
Date Deposited: 30 May 2019 10:51
Last Modified: 10 Sep 2021 14:10
DOI: 10.1038/s41433-019-0441-z
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3041765