Higher protein intake is associated with a lower likelihood of frailty among older women, Kuopio OSTPRE-Fracture Prevention Study.



Isanejad, Masoud, Sirola, Joonas, Rikkonen, Toni ORCID: 0000-0001-5948-1222, Mursu, Jaakko, Kröger, Heikki, Qazi, Sarang Latif, Tuppurainen, Marjo and Erkkilä, Arja T
(2020) Higher protein intake is associated with a lower likelihood of frailty among older women, Kuopio OSTPRE-Fracture Prevention Study. European journal of nutrition, 59 (3). 1181 - 1189.

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Abstract

<h4>Purpose</h4>Nordic nutrition recommendations (2012) suggest protein intake ≥ 1.1 g/kg body weight (BW) to preserve physical function in Nordic older adults. However, no published study has used this cut-off to evaluate the association between protein intake and frailty. This study examined associations between protein intake, and sources of protein intake, with frailty status at the 3-year follow-up.<h4>Methods</h4>Participants were 440 women aged 65─72 years enrolled in the Osteoporosis Risk Factor and Prevention-Fracture Prevention Study. Protein intake g/kg BW and g/d was calculated using a 3-day food record at baseline 2003─4. At the 3-year follow-up (2006─7), frailty phenotype was defined as the presence of three or more, and prefrailty as the presence of one or two, of the Fried criteria: low grip strength adjusted for body mass index, low walking speed, low physical activity, exhaustion was defined using a low life-satisfaction score, and weight loss > 5% of BW. The association between protein intake, animal protein and plant protein, and frailty status was examined by multinomial regression analysis adjusting for demographics, chronic conditions, and total energy intake.<h4>Results</h4>At the 3-year follow-up, 36 women were frail and 206 women were prefrail. Higher protein intake ≥ 1.1 g/kg BW was associated with a lower likelihood of prefrailty (OR = 0.45 and 95% confidence interval (CI) = 0.01-0.73) and frailty (OR = 0.09 and CI = 0.01-0.75) when compared to protein intake < 1.1 g/kg BW at the 3-year follow-up. Women in the higher tertile of animal protein intake, but not plant protein, had a lower prevalence of frailty (P for trend = 0.04).<h4>Conclusions</h4>Protein intake ≥ 1.1 g/kg BW and higher intake of animal protein may be beneficial to prevent the onset of frailty in older women.

Item Type: Article
Uncontrolled Keywords: Humans, Dietary Proteins, Geriatric Assessment, Follow-Up Studies, Aged, Frail Elderly, Diet Records, Finland, Female, Male, Fractures, Bone
Depositing User: Symplectic Admin
Date Deposited: 21 May 2019 11:47
Last Modified: 01 Oct 2021 12:53
DOI: 10.1007/s00394-019-01978-7
URI: https://livrepository.liverpool.ac.uk/id/eprint/3042179