Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum


Trivedi, DK, Sinclair, E, Xu, Y ORCID: 0000-0003-3228-5111, Sarkar, D, Walton-Doyle, C, Liscio, C, Banks, P, Milne, J, Silverdale, M, Kunath, T et al (show 2 more authors) (2019) Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum ACS Central Science, 5 (4). pp. 599-606. ISSN 2374-7943, 2374-7951

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Abstract

Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical test. We have serendipitously identified a hyperosmic individual, a "Super Smeller" who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort (n=31), identified a distinct volatiles-associated signature of PD, including altered levels of perillic aldehyde and eicosane, the smell of which was then described as being highly similar to the scent of PD by our "Super Smeller".

Item Type: Article
Uncontrolled Keywords: 34 Chemical Sciences, Neurodegenerative, Parkinson's Disease, Brain Disorders, Clinical Research, Neurosciences, Aging, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies, Neurological
Depositing User: Symplectic Admin
Date Deposited: 21 May 2019 14:43
Last Modified: 01 Mar 2026 00:19
DOI: 10.1021/acscentsci.8b00879
Open Access URL: https://pubs.acs.org/doi/10.1021/acscentsci.8b0087...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3042332
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