Metabolite changes in blood predict the onset of tuberculosis

Weiner, January III, Maertzdorf, Jeroen, Sutherland, Jayne S, Duffy, Fergal J, Thompson, Ethan, Suliman, Sara, McEwen, Gayle, Thiel, Bonnie, Parida, Shreemanta K, Zyla, Joanna
et al (show 11 more authors) (2018) Metabolite changes in blood predict the onset of tuberculosis. NATURE COMMUNICATIONS, 9 (1). 5208-.

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New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3-24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. These prognostic metabolic signatures are consistent with development of subclinical disease prior to manifestation of active TB. Metabolic changes associated with pre-symptomatic disease are observed as early as 12 months prior to TB diagnosis, thus enabling timely interventions to prevent disease progression and transmission.

Item Type: Article
Uncontrolled Keywords: GC6-74 consortium, Humans, Tuberculosis, Disease Progression, Sensitivity and Specificity, Prospective Studies, Adolescent, Adult, Africa South of the Sahara, Female, Male, Metabolomics, Metabolome, Young Adult, Biomarkers
Depositing User: Symplectic Admin
Date Deposited: 22 May 2019 13:53
Last Modified: 19 Jan 2023 00:43
DOI: 10.1038/s41467-018-07635-7
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