Imaging of cancer lipid metabolism in response to therapy

Arlauckas, Sean Philip, Browning, Elizabeth Anne, Poptani, Harish ORCID: 0000-0002-0593-3235 and Delikatny, Edward James
(2019) Imaging of cancer lipid metabolism in response to therapy. NMR IN BIOMEDICINE, 32 (10). e4070-.

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Lipids represent a diverse array of molecules essential to the cell's structure, defense, energy, and communication. Lipid metabolism can often become dysregulated during tumor development. During cancer therapy, targeted inhibition of cell proliferation can likewise cause widespread and drastic changes in lipid composition. Molecular imaging techniques have been developed to monitor altered lipid profiles as a biomarker for cancer diagnosis and treatment response. For decades, MRS has been the dominant non-invasive technique for studying lipid metabolite levels. Recent insights into the oncogenic transformations driving changes in lipid metabolism have revealed new mechanisms and signaling molecules that can be exploited using optical imaging, mass spectrometry imaging, and positron emission tomography. These novel imaging modalities have provided researchers with a diverse toolbox to examine changes in lipids in response to a wide array of anticancer strategies including chemotherapy, radiation therapy, signal transduction inhibitors, gene therapy, immunotherapy, or a combination of these strategies. The understanding of lipid metabolism in response to cancer therapy continues to evolve as each therapeutic method emerges, and this review seeks to summarize the current field and areas of unmet needs.

Item Type: Article
Uncontrolled Keywords: lipids, MRI, MRS, optical imaging, therapy response, tumor imaging
Depositing User: Symplectic Admin
Date Deposited: 30 May 2019 10:30
Last Modified: 19 Jan 2023 00:43
DOI: 10.1002/nbm.4070
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