Pharmaceutical approaches to weight management: behavioural mechanisms of action

Roberts, Carl A ORCID: 0000-0003-4275-601X, Christiansen, Paul and Halford, Jason CG (2019) Pharmaceutical approaches to weight management: behavioural mechanisms of action CURRENT OPINION IN PHYSIOLOGY, 12. pp. 26-32. ISSN 2468-8673, 2468-8673

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Abstract

Pharmacotherapy as an adjunct to behaviour modification, may provide an effective addition to individual weight management plans in specialised weight management services. There are four FDA approved centrally acting weight-loss drugs (liraglutide, bupropion/naltrexone, lorcaserin, phentermine/topiramate), and several additional candidate drugs yet to receive approval. Each drug has a distinct pharmacological mechanism of action, and presumably will support eating behaviour modification in different ways. Here, we assess to what extent behavioural mechanisms of action have been characterised. We recommend a methodological platform to be introduced pre-approval in order to achieve principal objectives of phase II and III trials (demonstrate efficacy), and afford stratification of responders to treatment, by behavioural and neurophysiological response.

Item Type:	Article
Uncontrolled Keywords:	3214 Pharmacology and Pharmaceutical Sciences, 32 Biomedical and Clinical Sciences, Obesity, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals
Depositing User:	Symplectic Admin
Date Deposited:	24 May 2019 11:56
Last Modified:	16 Jan 2026 05:07
DOI:	10.1016/j.cophys.2019.04.017
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3042783
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