Pharmaceutical approaches to weight management: behavioural mechanisms of action

Roberts, Carl A ORCID: 0000-0003-4275-601X, Christiansen, Paul and Halford, Jason CG ORCID: 0000-0003-1629-3189
(2019) Pharmaceutical approaches to weight management: behavioural mechanisms of action. CURRENT OPINION IN PHYSIOLOGY, 12. pp. 26-32.

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Pharmacotherapy as an adjunct to behaviour modification, may provide an effective addition to individual weight management plans in specialised weight management services. There are four FDA approved centrally acting weight-loss drugs (liraglutide, bupropion/naltrexone, lorcaserin, phentermine/topiramate), and several additional candidate drugs yet to receive approval. Each drug has a distinct pharmacological mechanism of action, and presumably will support eating behaviour modification in different ways. Here, we assess to what extent behavioural mechanisms of action have been characterised. We recommend a methodological platform to be introduced pre-approval in order to achieve principal objectives of phase II and III trials (demonstrate efficacy), and afford stratification of responders to treatment, by behavioural and neurophysiological response.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 24 May 2019 11:56
Last Modified: 19 Jan 2023 00:43
DOI: 10.1016/j.cophys.2019.04.017
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