Lambe, Tosin 
ORCID: 0000-0002-6229-2454, Adab, Peymane ORCID: 0000-0001-9087-3945, Jordan, Rachel E ORCID: 0000-0002-0747-6883, Sitch, Alice ORCID: 0000-0001-7727-4497, Enocson, Alex, Jolly, Kate ORCID: 0000-0002-6224-2115, Marsh, Jen, Riley, Richard ORCID: 0000-0001-8699-0735, Miller, Martin, Cooper, Brendan G et al (show 9 more authors)
(2019)
Model-based evaluation of the long-term cost-effectiveness of systematic case-finding for COPD in primary care.
Thorax, 74 (8).
pp. 730-739.
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Abstract
<h4>Introduction</h4>'One-off' systematic case-finding for COPD using a respiratory screening questionnaire is more effective and cost-effective than routine care at identifying new cases. However, it is not known whether early diagnosis and treatment is beneficial in the longer term. We estimated the long-term cost-effectiveness of a regular case-finding programme in primary care.<h4>Methods</h4>A Markov decision analytic model was developed to compare the cost-effectiveness of a 3-yearly systematic case-finding programme targeted to ever smokers aged ≥50 years with the current routine diagnostic process in UK primary care. Patient-level data on case-finding pathways was obtained from a large randomised controlled trial. Information on the natural history of COPD and treatment effects was obtained from a linked COPD cohort, UK primary care database and published literature. The discounted lifetime cost per quality-adjusted life-year (QALY) gained was calculated from a health service perspective.<h4>Results</h4>The incremental cost-effectiveness ratio of systematic case-finding versus current care was £16 596 per additional QALY gained, with a 78% probability of cost-effectiveness at a £20 000 per QALY willingness-to-pay threshold. The base case result was robust to multiple one-way sensitivity analyses. The main drivers were response rate to the initial screening questionnaire and attendance rate for the confirmatory spirometry test.<h4>Discussion</h4>Regular systematic case-finding for COPD using a screening questionnaire in primary care is likely to be cost-effective in the long-term despite uncertainties in treatment effectiveness. Further knowledge of the natural history of case-found patients and the effectiveness of their management will improve confidence to implement such an approach.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Pulmonary Disease, Chronic Obstructive, Early Diagnosis, Models, Economic, Markov Chains, Quality-Adjusted Life Years, Computer Simulation, Aged, Middle Aged, Cost-Benefit Analysis, Health Care Costs, Primary Health Care, Female, Male, United Kingdom, Smokers, Diagnostic Screening Programs |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 May 2019 10:25 |
| Last Modified: | 19 Jan 2023 00:42 |
| DOI: | 10.1136/thoraxjnl-2018-212148 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3042822 |
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