JmjC histone demethylases act as chromatin oxygen sensors



Batie, M ORCID: 0000-0002-7508-6641 and Rocha, S
(2019) JmjC histone demethylases act as chromatin oxygen sensors. Molecular and Cellular Oncology.

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Abstract

© 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 28 May 2019 09:28
Last Modified: 19 Jan 2022 09:16
DOI: 10.1080/23723556.2019.1608501
Open Access URL: https://doi.org/10.1080/23723556.2019.1608501
URI: https://livrepository.liverpool.ac.uk/id/eprint/3043292