JmjC histone demethylases act as chromatin oxygen sensors

Batie, M ORCID: 0000-0002-7508-6641 and Rocha, S (2019) JmjC histone demethylases act as chromatin oxygen sensors. Molecular and Cellular Oncology, 6 (4). 1608501-.

Access the full-text of this item by clicking on the Open Access link.

Text JmjC histone demethylases act as chromatin oxygen sensors.pdf - Published version Download (2MB) | Preview

Abstract

© 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia.

Item Type:	Article
Uncontrolled Keywords:	Hypoxia, JmjC-histone demethylases, chromatin, HIF. transcription
Depositing User:	Symplectic Admin
Date Deposited:	28 May 2019 09:28
Last Modified:	19 Jan 2023 00:42
DOI:	10.1080/23723556.2019.1608501
Open Access URL:	https://doi.org/10.1080/23723556.2019.1608501
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3043292