Myostatin-like proteins regulate synaptic function and neuronal morphology.

Augustin, Hrvoje ORCID: 0000-0002-2041-3844, McGourty, Kieran, Steinert, Joern R ORCID: 0000-0003-1640-0845, Cochemé, Helena M ORCID: 0000-0001-8637-0042, Adcott, Jennifer ORCID: 0000-0001-9146-3171, Cabecinha, Melissa, Vincent, Alec ORCID: 0000-0002-9201-2900, Halff, Els F ORCID: 0000-0001-5814-0899, Kittler, Josef T ORCID: 0000-0002-3437-9456, Boucrot, Emmanuel ORCID: 0000-0001-7312-6462
et al (show 1 more authors) (2017) Myostatin-like proteins regulate synaptic function and neuronal morphology. Development (Cambridge, England), 144 (13). pp. 2445-2455.

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Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of myostatin and its cognate receptors in other tissues, including brain and peripheral nerves, suggests a potential wider biological role. Here, we show that Myoglianin (MYO), the <i>Drosophila</i> homolog of myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner. Both myostatin and GDF11 affected synapse formation in isolated rat cortical neuron cultures, suggesting an effect on synaptogenesis beyond neuromuscular junctions. We also show that MYO acts <i>in vivo</i> to inhibit synaptic transmission between neurons in the escape response neural circuit of adult flies. Thus, these anti-myogenic proteins act as important inhibitors of synapse function and neuronal growth.

Item Type: Article
Uncontrolled Keywords: Neuroglia, Neurons, Neuromuscular Junction, Synapses, Muscle Cells, Animals, Humans, Rats, Drosophila melanogaster, Body Weight, Glycogen Synthase Kinase 3, Transforming Growth Factor beta, Drosophila Proteins, Signal Transduction, Cell Shape, Synaptic Transmission, Down-Regulation, Gene Silencing, Larva, Growth Differentiation Factors, Myostatin
Depositing User: Symplectic Admin
Date Deposited: 31 May 2019 09:17
Last Modified: 17 Mar 2024 21:04
DOI: 10.1242/dev.152975
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