Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010-2017.



Adler, Hugh, Nikolaou, Elissavet, Gould, Katherine, Hinds, Jason, Collins, Andrea M, Connor, Victoria, Hales, Caz, Hill, Helen, Hyder-Wright, Angela D, Zaidi, Seher R
et al (show 8 more authors) (2019) Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010-2017. The Journal of infectious diseases.

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Abstract

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 31 May 2019 10:34
Last Modified: 11 Jan 2022 12:47
DOI: 10.1093/infdis/jiz034
Open Access URL: https://doi.org/10.1093/infdis/jiz034
URI: https://livrepository.liverpool.ac.uk/id/eprint/3043832