Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography



Zhang, Zijian ORCID: 0000-0002-3004-6697, Williams, Bryan ORCID: 0000-0001-5930-287X, Zheng, Yalin ORCID: 0000-0002-7873-0922, Lin, Hungyen and Shen, Yaochun ORCID: 0000-0002-8915-1993
(2019) Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. COATINGS, 9 (5). p. 326.

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Abstract

<jats:p>Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.</jats:p>

Item Type: Article
Uncontrolled Keywords: pharmaceutical film coating, thin coating, 500-mg paracetamol tablet, GSK Panadol, generic paracetamol, optical coherence tomography, image segmentation, differentiation
Depositing User: Symplectic Admin
Date Deposited: 04 Jun 2019 07:29
Last Modified: 19 Jan 2023 00:41
DOI: 10.3390/coatings9050326
Open Access URL: https://doi.org/10.3390/coatings9050326
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3044240