Penrose, AJ
(2019)
Investigating the role of eyes absent homolog 1 (EYA1) in aspirin-induced gastric ulceration
PhD thesis, University of Liverpool.
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Abstract
Non-selective NSAIDs are some of the mostly commonly used drugs worldwide; over 60 million US citizens regularly take NSAIDs while 30% of the general population use low-dose aspirin for cardiovascular disease prevention. NSAID use increases the risk of GI complications by 3-5 times compared to non-use. Estimates of NSAIDrelated mortality rates are between 3,200-16,500 in the USA and 400-1,000 in the UK, with the economic burden estimated to be over 3 billion USD a year in the USA alone. Whilst the majority of the adverse GI effects caused by NSAIDs are presumed to be dependent on the inhibition of COX-1-mediated prostaglandin synthesis, prostaglandin-independent mechanisms are also important in ulcer pathogenesis. Various genetic risk factors have been identified for NSAID-induced gastric injury. Uncovering the role of these polymorphisms has provided a better understanding of the mechanism through which NSAIDs cause gastric ulceration and bleeding. A genome-wide association study recently identified a novel association between a polymorphism in the Eyes Absent Homolog 1 (EYA1) gene and gastric ulceration. EYA1 is a transcriptional cofactor that plays an important role in organogenesis and has more recently ... (continues)
| Item Type: | Thesis (PhD) |
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| Uncontrolled Keywords: | Non-steroidal anti-inflammatory drugs, NSAIDs, Aspirin, Peptic ulceration, Pharmacogenetics, EYA1, Eyes absent homolog 1, Adverse drug reaction |
| Divisions: | Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > School of Medicine |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Aug 2019 10:15 |
| Last Modified: | 07 Feb 2025 13:28 |
| DOI: | 10.17638/03044269 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3044269 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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