Luque, S, Hope, W 
ORCID: 0000-0001-6187-878X, Campillo, N, Munoz-Bermudez, R, Sorli, L, Barcelo-Vidal, J, Gonzalez-Colominas, E, Alvarez-Lerma, F, Masclans, JR, Montero, M et al (show 2 more authors)
(2019)
Population Pharmacokinetics of Anidulafungin in Critically III Patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 63 (7).
e00378-e00319.
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Abstract
A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations suggested that patients with higher TBWs had less-extensive MIC coverage. Dosage escalation may be warranted in patients with high TBWs to ensure optimal drug exposures for treatment of <i>Candida albicans</i> and <i>Candida glabrata</i> infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Candida, Monte Carlo simulation, anidulafungin, critical care unit, pharmacokinetics/pharmacodynamics |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Jun 2019 08:07 |
| Last Modified: | 13 Feb 2024 09:16 |
| DOI: | 10.1128/AAC.00378-19 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3044521 |
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