Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16.



Pebody, Richard G, Sinnathamby, Mary A, Warburton, Fiona, Andrews, Nick, Boddington, Nicola L, Zhao, Hongxin, Yonova, Ivelina, Ellis, Joanna, Tessier, Elise, Donati, Matthew
et al (show 7 more authors) (2018) Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 23 (25).

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Abstract

The 2015/16 influenza season was the third season of the introduction of an intra-nasally administered live attenuated influenza vaccine (LAIV) for children in England. All children aged 2‒6 years were offered LAIV, and in addition, a series of geographically discrete areas piloted vaccinating school-age children 7‒11 years old. Influenza A(H1N1)pdm09 was the dominant circulating strain during 2015/16 followed by influenza B. We measured influenza vaccine uptake and the overall and indirect effect of vaccinating children of primary school -age, by comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot and non-pilot areas in England. Uptake of 57.9% (range: 43.6-72.0) was achieved in the five pilot areas for children aged 5‒11 years. In pilot areas, cumulative emergency department respiratory attendances, influenza-confirmed hospitalisations and intensive care unit admissions were consistently lower, albeit mostly non-significantly, in targeted and non-targeted age groups compared with non-pilot areas. Effect sizes were less for adults and more severe endpoints. Vaccination of healthy primary school-age children with LAIV at moderately high levels continues to be associated with population-level reductions in influenza-related respiratory illness. Further work to evaluate the population-level impact of the programme is required.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 05 Jun 2019 09:46
Last Modified: 17 Jan 2020 12:10
DOI: 10.2807/1560-7917.ES.2018.23.25.1700496
Open Access URL: https://doi.org/10.2807/1560-7917.ES.2018.23.25.17...
URI: http://livrepository.liverpool.ac.uk/id/eprint/3044550